3 × 3 Eyes follows Yakumo Fuuji, a young man who, through a series of strange events, becomes the immortal slave of the last member of a race of three‑eyed immortals. In order to save his life, the immortal absorbs Yakumo’s soul, rendering him immortal as well. Together, they embark on a quest to discover a way for Yakumo to regain his humanity. Along the way, complications arise, not least of which is the immortal’s split personality, one side is achingly cute, while the other exudes no‑nonsense destructive power, and the romances that develop between them.