Hyakkimaru is a young man missing 48 body parts that were taken from him by demons before he was born, in exchange for his father, Kagemitsu Daigo, gaining the power to seize control of the country. Born without those parts, the infant was abandoned and thrown into a river. As he grew, Hyakkimaru acquired prosthetic body parts to confront and defeat the 48 demons that were created from his missing body pieces, and to reclaim them. He is joined on this journey by Dororo, a street‑wise thief, with whom he forms a close friendship.