Koume-chan ga Iku! follows Koume, a fresh graduate who joins Caramel Ribbon, Inc., a design firm in Osaka. The series chronicles her daily and nightly adventures, highlighting the humor that is uniquely Osaka and, by extension, Kansai, a region that feels distinct from the rest of Japan. Even viewers with no prior knowledge of the area will gain insight into the culture. The show is a lighthearted look at office life, featuring Koume alongside her effeminate boss and Kimi, a former girl‑gang member, as they work to promote new and innovative designs. The cast of voice actors hail from Kansai, lending an authentic flavor to the dialogue. Koume-chan ga Iku! is part of the Anime no Ai Awa Awa Hour (アニメ愛のあわあわアワー), a trio of relationship‑focused comedies aimed at women that aired on the network.