Masane Amaha and her daughter Rihoko flee from a government child‑welfare agency determined to separate them. Their escape ends when they are captured, and Rihoko is taken away. As Masane confronts an advanced weapon that can disguise itself as a human, a strange light radiates from her wrist, transforming her into a powerful being. She destroys the weapon and, as a result, becomes the focal point of a power struggle among several influential organizations. Possessing the legendary Witchblade, the most potent force in the conflict, Masane is drawn into a battle that places her at the center of their attention.