Takato Matsuda, Ruki Matsuno, and Lee Jenrya are children who, by fate, have encountered real Digimon, unlike the imaginary creatures featured in the card game they play. Each of the children, known as Digimon Tamers, holds a different perspective on how to treat their Digimon partners. When other Digimon begin appearing across Japan, the trio must set aside their disagreements and work together to repel the digital intruders, even as Yamaki, the head of the secret organization Hypnos, seeks to eliminate all Digimon.